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Quick answer Injectable semaglutide (Ozempic, Wegovy) has a half-life of about 1 week, and tirzepatide (Mounjaro, Zepbound) about 5 days

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Current FDA guidance notes that semaglutide carries a theoretical black-box warning for personal or family history of medullary thyroid carcinomaa genuine contraindicationbut population-level cancer surveillance shows no increased incidence

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There's a lot of confusion right now