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Preclinical studies suggest that liraglutide interacts with circumventricular organs but was also found in the arcuate nucleus (ARC) and paraventricular nucleus (PVN), which is protected by the BBB and suggests other ways of transport other than passive diffusion [23]
To contextualise that number: the landmark STEP 1 trial of semaglutide 2.4 mg showed a mean weight loss of approximately 14.9%, and the SURMOUNT-1 trial of tirzepatide reached 20.9% at its highest dose [2, 3]
For an additional insight into the mechanism of action, the tumorous tissue was stained with a ROS-specific dye and analyzed by CLSM
J., Vilsbll, T
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[1] [2] This triple-receptor mechanism distinguishes it from currently approved agents such as semaglutide (a GLP-1 agonist) and tirzepatide (a dual GIP/GLP-1 agonist)
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