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In anterograde regulation, proteins encoded by the nuclear genome are transferred to the mitochondria to perform functions (71), while in retrograde regulation, the signal generated from mitochondria passes into the nucleus to induce gene expression, which occurs when mitochondrial homeostasis is interrupted by hypoxia or mutation in mtDNA, or mitochondrial Ca 2+ release (72, 73)
10.1074/jbc.M410508200 171 KanekuraK.HashimotoY.NiikuraT.AisoS.MatsuokaM.NishimotoI
Cardiovascular health: L-Carnitine plays a role in reducing oxidative stress, improving circulation, and supporting overall heart health
More serious potential risks include (not an exhaustive list): Pancreatitis
It risks infection
