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large doses might diminish the effectiveness of antidiabetic medications (like insulin, metformin, or sulfonylureas)

Blocking NNMT is expected to raise SAM availability, but SAM participates in many cellular processes, so research must establish that selectively raising it does not perturb other methylation pathways

Chen H, Wu J, Sun M, Guo C, Yu A, Cao F, Zhao L, Tan Q, Zhai G

The combination group showed significantly higher improvement scores than the dermaroller-only group at baseline and Week 3, with p-values indicating statistically significant differences