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N Engl J Med 2024;391:299-310

Managing the Risks: A Proactive Approach If you and your healthcare provider decide to move forward with a weight loss program using GLP-1s, a gut-first strategy is essential

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Nauseaa known side effect of GLP-1 therapymay worsen if you fast for extended periods without electrolytes or adequate hydration, so consider a pinch of salt in your water or a sugar-free electrolyte drink during fasting windows if nausea emerges

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Studies in adults without diabetes show that GLP-1 drugs reduce appetite and calorie intake, which helps explain why weight loss happens