Other Affordable GLP-1 Options Available Without Insurance Beyond semaglutide, PlexusDx offers compounded tirzepatide (a dual GIP/GLP-1 receptor agonist) at $289/mo month-to-month, or from $249/mo on the 6-month plan, oral formulations of both medications, and the GLP-Squared dual-compound injection at $289/mo (or $249/mo on the 3-month plan)
However, its entirely another matter if youre seeking Semaglutide solely for weight loss
In December 2025, the FDA approved the first oral GLP-1 pill for weight management, and compounding pharmacies have introduced oral disintegrating tablet (ODT) formulations that bypass the digestive system entirely
However, this relationship diminished considerably after additional adjustments for these demographic factors [6]
Unpredictable blood sugar changes: Although gastroparesis doesnt cause diabetes, it can make blood sugar levels unpredictable, making diabetes worse
For thorough tissue support during weight loss, the injectable form (with or without additional topical use) is recommended by most physicians