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In protocol 2 there were 81 617 participants (16 768 in the GLP-1 receptor agonist group and 64 849 in the SGLT-2 inhibitor group) (table 3, table 4, and supplementary table S10), totalling 205 451 person years of follow-up
The first incretin-based drug specifically for weight loss was approved by the FDA in 2014 for adults with obesity or who were overweight with at least one weight-related condition
Mood Outside emotional factors can also impact sex drive
As diabetes drugs continue to evolve, clinicians must stay informed about emerging therapies, expanded indications, and safety considerations to optimize patient outcomes
Japan's PMDA often requires Japan-specific clinical data, which could delay approval there
However, these trials had relatively short follow-up periods and excluded patients at high risk for MTC, limiting the ability to detect rare events or long-term risks
