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Effectiveness and safety of glucagon-like peptide 1 receptor agonists in patients with type 2 diabetes: evidence from a retrospective real-world study

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It has been hypothesized that a reduction in hepatic GCGR and signaling molecules affects a feedback mechanism acting on the pancreatic alpha cells, increasing glucagon secretion, and this liver-pancreas axis might contribute to fasting hyperglucagonemia (36)

Prior to the arrival of GLP1 receptor agonists, weight loss medications had modest impacts on weight loss and were frequently poorly tolerated

doi: 10.1007/s40273-014-0243-x 5

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