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doi: 10.1016/j.biocel.2007.04.014 228 RahmanI.MacNeeN

630 Caloric restriction regimen translates into increased astrocytic complexity, size of astrocytic territorial domains and volume of perisynaptic leaflets, paralleled with an improved glutamate clearance and K + buffering, all improving synaptic plasticity

Mugler, J

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When compared to matched normal thyroid tissue, both benign (human follicular adenomas, or FTAs) and malignant (follicular (FTC) and papillary thyroid carcinoma (PTC)) lesions were found to have elevated nuclear levels of 8-oxo-dG (118) which most likely reflects the detrimental effects of prolonged exposure to chronic OxS seen during thyroid cancer (113, 118)

Higher dose therapies can take up to 3 hours and have to be administered slowly and safely