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These vasoprotective effects may be mediated through GLP-1 receptor signaling pathways, including activation of protein kinase A (PKA) and phosphoinositide 3-kinase (PI3K) pathways, and modulation of endothelial cell survival and apoptosis regulators

Hasanzadeh E, Mohammadi M-R, Ghanizadeh A, Rezazadeh S-A, Tabrizi M, Rezaei F, Akhondzadeh S (2012) A double-blind placebo controlled trial of Ginkgo biloba added to risperidone in patients with autistic disorders

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[23] [24] Cost-effectiveness considerations should include: Treatment duration : Both medications typically require long-term use, with weight regain common after discontinuation