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Continuous Use There is limited research on optimal cycling strategies (periods of use followed by breaks) versus continuous use

[1] Niacinamide in high doses can sometimes cause nausea, heartburn, or a sensation of warmth

With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels

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Food, stress, infections, alcohol, and some drugs can add friction to the lining