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Additionally, iron overload may enhance platelet aggregation and thrombosis, increasing the risk of acute coronary events (2628)

For Biomarker Research, the most promising direction is not a single universal metabolite but a phenotype-aware, pathway-anchored biomarker strategy that integrates circulating metabolites with imaging, clinical context, and validated outcomes

Significant increase in the abundance of serine proteases is consistent with the upregulation of proteolytic enzymes reported by 3.5 Peroxisomal proteins involved in -oxidation and detoxification of reactive species are upregulated Peroxisomes are important organelles involved in lipid homeostasis, ROS detoxification, and secondary metabolite metabolism (Steinberg, 2016)