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The SURMOUNT-5 study confirmed a direct comparison: participants on tirzepatide lost an average of 23 kg, on semaglutide 15 kg [2]
Approved Uses for Semaglutide Semaglutide is approved for two main uses
It restores normal nerve function and supports red blood cell production by correcting Vitamin B12 deficiency
Prior therapy and weight loss Adults who used semaglutide as their first obesity medication lost more body weight at all timepoints than those who used a previous obesity medication
Concurrently, GLP-1 receptor activation stimulates glucose-dependent insulin release, suppresses inappropriate glucagon secretion, slows gastric emptying, and reduces appetite through central nervous system pathways
Different people will have different responses to each of these drugs
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