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On the contrary, GGTs from extremophiles exhibit variability in their catalytic residues with respect to their mesophilic counterparts as has been revealed by multiple sequence alignment (Supplementary Figure 1)

These degenerative processes all contribute to synapse loss, neuronal death, and cognitive decline, emphasizing the need for multi targeted treatment approaches

Front Psychiatry 8:278204

In addition, ROS could also damage the skin in the following ways: activating transcription factors, upregulating the expression levels of EGF receptor in human keratinocytes (31), inducing ferroptosis etc

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found that DEPMPO, an -phosphorus-containing analogue of DMPO, reacts with O 2 to form DEPMPO/ OOH, which is 15 times more stable than DMPO/ OOH 33