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This was defined as a 1-point to 2-point decline in the Revised ALS Functional Rating Scale (ALSFRS-R) total score over an initial three-month observational period
Many people dont absorb B12 as well when taken orally
High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy
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