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Both compounds have attracted interest for metabolic health, particularly in individuals with insulin resistance, metabolic syndrome, or PCOS

Specifically, retatrutide is intended to activate the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor a combination that distinguishes it from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 receptor agonist)

Never apply patches over broken, irritated, or diseased skin

People who have not seen success with other weight loss medications or treatments

People with acromegaly are more likely to develop cardiovascular problems