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Moreover, Cyp2e1-/- mice showed resistance to the APAP high dose-associated hepatotoxicity, whereas human CYP2E1 transgenic mice were susceptible, suggesting that CYP2E1 is the major P450 enzyme participating in APAP activation ( via O-glucuronidation (50%70%) and O-sulfation (approximately 25%) pathways and forms the corresponding conjugates that can be easily excreted by the kidney

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Furthermore, it increases the concentrations of anti-inflammatory cytokines interleukin 10 and interleukin 12P40, while also enhancing the expression of angiogenic and neurogenesis factors, such as vascular endothelial growth factor A and interleukin 7 (Faycal Guedj et al

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As for treatment protocol, wound treatments were applied once daily, before re-bandaging, for 21 days