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One of the problems that have emerged, especially when many of these drugs have been tested in vitro for their inhibition properties, is their lack of specificity

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However, large-scale human trials remain limited and results vary

In those preclinical models it has been reported to promote angiogenesis the growth of new blood vessels through the VEGFR2AkteNOS / nitric-oxide pathway, which may help explain its observed effects on healing [1] [4]

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