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Future trials should prioritize sufficient duration ( 1218 months), include high-risk subgroups (e.g., older adults, frail individuals, patients with rapid or marked weight loss, or chronic comorbidities such as chronic kidney disease), and integrate nutritional and resistance training interventions

The search covered studies published between January 1, 2000, and December 31, 2025

Selank is a synthetic peptide developed from a naturally occurring immune peptide called tuftsin

Understanding the True Cost of GLP-1s Without Insurance The financial commitment extends beyond initial medication expenses, encompassing both immediate costs and extended treatment duration requirements

Statements Author contributions YZ and WY wrote the draft manuscript

New combination treatments in the management of diabetes: focus on sitagliptin-metformin