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Diabetologia 57 (4), 781784
PMID: 7595745
The vacuum inside the vial is intentional
Anticipated uses: Obesity management (with or without diabetes) Type 2 diabetes Fatty liver disease (potentially pending NASH approval) Retatrutide vs Tirzepatide: Summary Comparison Conclusion Tirzepatide has changed the game in obesity and diabetes carebut retatrutide is poised to redefine the future of metabolic medicine
CDR-SB is the Clinical Dementia Rating Sum of Boxes a single score that measures how well someone with Alzheimer's can think and function in daily life
If considering a dose reduction for maintenance: Wait until weight has stabilized for at least 4 weeks at your current dose Reduce by one dose step (e.g., 12mg to 8mg), do not jump multiple steps Monitor weight closely for 8 weeks after the reduction If weight begins to increase, return to the previous maintenance dose The phase 3 trials specifically tested 4mg as a maintenance dose, suggesting Lilly sees viability in lower maintenance doses What happens if you stop Weight regain after discontinuing GLP-1 agonists is well documented with semaglutide and tirzepatide
