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NICE obesity guidance (CG189) recommends multicomponent interventions addressing diet, physical activity, and behaviour change as first-line management

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Clinical experience from thousands of patients in optimization medicine practices supports its use, but the formal evidence lags behind the clinical adoption

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Downstream transcription factors showed dramatic upregulation: c-Fos by 4.99-fold, c-Jun by 7.05-fold, and Egr-1 by 3.70-fold