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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility

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Decreased stomatal conductance results decline in the rate of photosynthesis by limiting the uptake of CO 2, while high stomatal conductance favors high photosynthesis output 43,44

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