GH pulses lead to hepatic IGF-1 secretion, which stimulates myogenesis and hypertrophy, particularly under resistance training conditions. Thorner et al., Nature Reviews Endocrinology 5
Gut-liver axis, nutrition, and non-alcoholic fatty liver disease
doi: 10.1016/S0140-6736(14)61468-9 132 KimMPlattMJShibasakiTQuagginSEBackxPHSeinoSet al
Joint Stiffness or Discomfort Elevation of GH may result in temporary joint stiffness as the tissues are adapting to the increased regenerative activity, particularly during the first few weeks
However, it also co-stimulates ACTH and cortisol to a greater degree than any other GHRP, an effect attributed to partial receptor activity at pituitary corticotroph populations and direct adrenal stimulation in some models
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