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However, the functional consequences of these changes are highly context-dependent and may vary according to tissue type, exposure duration, and regulatory mechanisms
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In addition to the well-established extracellular GSH degradation mechanism, studies have shown an additional intracellular hydrolysis pathway for GSH degradation (47,48)
In accordance to the ACMG criteria, the variant was classified as variant of uncertain significance (VUS) [13]
In these cases, glutathione (GSH) levels are well below the normal concentration and therefore feedback inhibition of GCL is absent
Hepatotoxicity after 3-hydroxyacetanilide administration to buthionine sulfoximine pretreated mice
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