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Here's why: when you're losing weight on a GLP-1, your body doesn't just lose fat
References: Kim et al
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These include several deiodinase enzymes that are essential for the generation of thyroid hormones, several glutathione peroxidases that are important for the conversion and detoxification of compounds with reactive oxygen atoms, and several proteins of unknown function
Each receptor has its own dose-response curve, and finding the right balance between GLP-1, GIP, and glucagon activation requires careful escalation
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