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16 December 2016
The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)
Good urinary hygiene, such as urinating after sexual intercourse and avoiding irritants like scented soaps and douches, is also advised
2015 Hayes MR, Mietlicki-Baase EG, Kanoski SE, et al
Room-temperature liquid dissolves lyophilized material more readily
However, the effect of baseline gastroparesis or other comorbidities or use of other medications that could impact gastric emptying independent of GLP-1RA use were not studied
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