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Exercise is known to increase BDNF in the retina and serum (160, 162, 217, 225), and in rodent retinal injury models, exogenous irisin, a myokine that upregulates BDNF, attenuates neuroinflammation and ganglion cell death, supporting a broader exerkine-BDNF pathway in retinal neuroprotection (162, 219, 239)

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Following DOX therapy in rats, one of the most noteworthy events was the considerable decrease in E2, which indicated that the OGCs were less able to produce E2

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