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Phase Maintenance Weeks 25+ Retatrutide 12 mg/week Cagrilintide 2.4 mg/week Notes Full four-receptor coverage if tolerated

Oral drops and oral tablets: Available in addition to injections for patients seeking non-injectable options

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Pharmacists Perspective Faryal Faisal, PharmD Patients who quit semaglutide most often do so during weeks 26, when side effects peak but weight loss has not yet visibly started

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The meta-analysis by Tuersun found no significant difference in body weight reduction when comparing the combination therapy to either GLP-1RA monotherapy or SGLT2i monotherapy: this finding challenges the assumption of a synergistic or additive effect on weight loss [15]