The STEP UP trial, published in The Lancet Diabetes & Endocrinology in September 2025, showed 18.7% average weight loss at 72 weeks compared to 15.6% at the standard 2.4 mg dose
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Its very serious, Victoria Copeland, founder of the organization Empowerment Through Community who lives with long COVID, said in her remarks on Wednesday
Additionally, Truveta Research found that weight loss was greater for patients without type 2 diabetes than for those with evidence of type 2 diabetes, though differences in effectiveness between tirzepatide and semaglutide were similar
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The participants provided their written informed consent to participate in this study