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It is large (4,813 daltons), predominantly hydrophilic (water-soluble peptide backbone), and requires doses in the milligram range
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Diabetes Care 29, 2632-2637
FDA's concerns include potential immunogenicity for certain administration routes, peptide-related impurities, and the fact that Ipamorelin acetate contains unnatural amino acids that add characterization complexity
1 H- 1 H NOESY NMR Spectroscopy The same samples used for the SNAC titration with 50 mM CTAB were also used for the NOESY experiments
Kessler, R
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