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From previous investigations, a therapeutic dosage of different authorized DPP-IV inhibitors led to a two- to threefold raise in endogenous GLP-1 concentration without any inherent hypoglycemia risk and a favorable safety profile ( Figure 2 )

Apply light pressure with an alcohol pad after withdrawal if any bleeding occurs

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Some lyophilization processes create denser powder requiring 5-10 minutes hydration before complete dissolution

Redox Biology , 6, 198-205