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Health conditions, in general, can affect the rate of metabolism
Thats how GLP-1 agonists work to control blood sugar in diabetic patients
Women of childbearing potential should be counseled that Wegovy is contraindicated in pregnancy
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contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Risk of diabetic retinopathy complications in patients with pre-existing retinopathy Potential for acute kidney injury, particularly related to dehydration Caution or avoidance in severe gastroparesis or severe gastrointestinal disease Suicidality warning for weight-management indications (Wegovy, Saxenda) Potential for altered absorption of oral medications due to delayed gastric emptying In older adults with cognitive impairment, medication adherence may be challenging, and gastrointestinal side effects could lead to dehydration or nutritional deficiencies
Procedures Participants were randomly assigned to receive orforglipron at a dose of 12 mg, 24 mg, 36 mg, or 45 mg or placebo once daily for 36 weeks
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