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The STEP 1 clinical trial demonstrated average weight loss of approximately 15% of body weight over 68 weeks with semaglutide 2.4mg, but these results were achieved in conjunction with dietary counselling and a 500 kcal per day calorie deficit, as highlighted in NICE TA875

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In fact, many health-conscious individuals find that taking them in tandem creates a more robust foundation for their wellness goals

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Even more impressively, they saw a massive 260% increase in exfoliated buccal (inner cheek) cells

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in both study groups, the mean age was 65 years, 16% had higher education and 28% had a history of ischaemic heart disease (Table 1)

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