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Do not take another dose until at least 72 hours have elapsed

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1D), the mRNA and protein expression levels of GLP-1R were significantly increased in ASM cells transfected with pcDNA3.1-Glp-1R for 72 h, and significantly decreased in those transfected with GLP-1R siRNA for 48 h

In the decades since, researchers have repeatedly returned to it as an open question in neurochemistry, with one influential review aptly describing it as a "still unresolved riddle" (Kovalzon et al., 2006)

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