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The ability to uncover these multi-target and multi-pathway mechanisms is a unique strength of genomics technology
By interacting with temperature regulation, it affects the endocrine system and alleviating of hypothermia
thus, it readily reacts with the SH group of G-site bound GSH to form a disulfide linkage 22,23
doi:10.1097/NRL.0b013e318266f58a 15.Bosoi C, Rose C
reported that PCA alleviated metabolic-associated fatty liver disease (MAFLD) by inhibiting Enterococcus faecalis growth, reducing inflammatory cytokine production, and limiting lipid peroxidation (Tan et al., 2023)
In addition to addressing these knowledge gaps in our understanding of topical tranexamic acid as a treatment option for melasma, further studies on the minimum systemic dose may address the downside of cost and potential for complications that may limit the use of this medication in the US
