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Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use

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Alternatively, low B12 may have a direct effect on the progression of Parkinsons disease, or it may be a marker of an unknown associated factor, perhaps correlating with another aspect of the disease or nutritional status. The study was published March 6, 2018, in the early view version of the journal Movement Disorders