What evidence is there that such immunity exists
The "as needed" approach reflects that NAD+ is a coenzyme, not a receptor agonist there's no desensitization concern in the same way
The 5-amino-1mq dosage protocol we've observed in institutional settings typically starts at 50mg daily for two weeks, then escalates to 75100mg based on tolerance and objective metabolic markers (NAD+ levels, methylnicotinamide urinary excretion)
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Slower systemic results: For musculoskeletal injuries or systemic inflammation, oral dosing may be less effective
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