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GLP-1 Receptor Agonists and SGLT2 Inhibitors in Type 2 Diabetes: Pleiotropic Cardiometabolic Effects and Add-on Value of a Combined Therapy
The in vivo study utilized naturally aged male C57BL/6 mice between 20-24 months old and young adult male C57BL/6 mice that were 3 months old
The juxta-epithelial region shows the presence of diffuse melanin pigmentation along with the presence of melanocytes and melanophages (macrophages that engulf the melanin pigment)
10.1038/302716a0 9 BornerT.ShaulsonE
Research has consistently shown a synergistic GH pulse that substantially exceeds either peptide alone, with downstream improvements in lean body mass, fat metabolism, tissue repair, and sleep quality particularly when timed around nocturnal GH secretion