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May also interact with FGF pathways based on observed effects on fibroblast proliferation
Combined treatment with CDK4/6 and IGF-IR inhibitors synergistically inhibits Ewing sarcoma [132]
14 AST exists as two genetically and immunologically distinct isoenzymes, namely cytoplasmic AST and mitochondrial AST
11,78 Moreover, suppressing either component of system Xc induces ferroptosis by disturbing cystine uptake, then limiting GSH synthesis
FOXO transcription factors differ in their dynamics and intra/intermolecular interactions
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