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The glucose-dependent insulinotropic polypeptide receptor (GIPR) functions similarly but may also be expressed in - and possibly -cells, modulating glucagon and somatostatin secretion (Shilleh et al., 2024)

This response typically stems from rapid metabolic shifts, dehydration, and changes in blood sugar regulation as your body adjusts to GLP-1 therapy

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At this stage, progress is often easier to maintain with continued use