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Inform patients of the signs and symptoms of acute kidney injury and instruct them to promptly report any of these signs or symptoms or persistent (or extended) nausea, vomiting, and diarrhea to their healthcare provider [see Warnings and Precautions (5.3)]
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59 These findings suggest that vesicle-mediated signaling may either amplify or restrain ferroptosis depending on cargo composition and uptake efficiency, highlighting extracellular vesicles as bidirectional regulators of ferroptotic susceptibility rather than unidirectional death signals
