The disease is characterized by: *Chronic lymphocytic infiltration of the thyroid gland *Elevated TPO antibodies (TPOAb) - present in over 90% of cases *Elevated thyroglobulin antibodies (TgAb) - present in 5080% of cases *Progressive thyroid fibrosis and loss of function *Eventual hypothyroidism requiring lifelong levothyroxine replacement The Oxidative Stress Signature of Hashimoto's The Antioxidants review (2021) confirmed that patients with Hashimoto's thyroiditis show a consistent pattern of oxidative stress markers: elevated malondialdehyde (MDA - a lipid peroxidation marker), reduced superoxide dismutase (SOD) activity, and critically, significantly decreased glutathione levels compared to healthy controls
It plays a crucial role in childbirth and lactation, prompting uterine contractions during labor and milk release during breastfeeding, hence its medical use in inducing and augmenting labor and managing postpartum bleeding [31]
The science is moving fast
Key Points Interested in Dr
Farias JG, Bustos-Obregn E, Orellana R, Bucarey JL, Quiroz E, Reyes JG
doi:10.1126/science.3353726
