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EUPAS ID: EUPAS48148), this study aimed to better understand changes in patient characteristics and treatment patterns corresponding with updates to clinical guideline recommendations and drug labeling and the emergence of new CKD-protective therapies such as finerenone in the US in 20212022
The expression of VE-cadherin (VE-Cad), an adherens junction protein and a key regulator of endothelial barrier function [77], was assessed in this model, showing cell elongation, which indicates the presence of a tight endothelial-like monolayer [43, 44]
This creates an interesting pharmacological paradox
Recent epidemiological studies have identified the glucose 6-phosphate dehydrogenase (G6PD) gene on the X chromosome as one possible location of such genetic variants
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