Abbreviations 3PG: 3-Phosphoglycerate KG: -Ketoglutarate Ac-CoA: Acetyl-coenzyme A ATP: Adenosine triphosphate ATP5F1B: ATP synthase subunit beta BDNF: Brain-derived neurotrophic factor CDKL5: Cyclin-dependent kinase-like 5 Cit: Citrate CM: Cortical neuron medium CS: Citrate synthase Ct: Cycle threshold DCX: Doublecortin dox: Doxycycline DPBS: Dulbeccos phosphate-buffered saline E4P: Erythrose 4-phosphate E8: Essential 8 ETS: Electron transport system F6P: Fructose 6-phosphate FC: Fold change FCCP: Carbonylcyanide-p-trifluoromethoxyphenylhydrazone FLIM: Fluorescence lifetime imaging microscopy Fum: Fumarate G3P: Glyceraldehyde-3-phosphate G6P: Glucose 6-phosphate G6PD: Glucose-6-phosphate dehydrogenase GABA: -Aminobutyric acid Glc: Glucose Gln: Glutamine Glu: Glutamate GLUT1: Glucose transporter 1 Gly: Glycine GOBP: Gene Ontology Biological Process GSEA: Gene Set Enrichment Analysis GSH: Glutathione HDAC: Histone deacetylase HILIC: Hydrophilic interaction chromatography hnRNP-E1: Heterogeneous nuclear ribonucleoprotein E1 iNs: NGN2-induced neurons iNs_D7: NGN2-induced neurons at day 7 iNs_D14: NGN2-induced neurons at day 14 iPSCs: Induced pluripotent stem cells IRF: Instrument response function KEGG: Kyoto Encyclopedia of Genes and Genomes LC-MS: Liquid chromatography-mass spectrometry LFQ-MS: Label-free quantitative mass spectrometry NAD(P)H: Nicotinamide adenine dinucleotide (phosphate) NANOG: Nanog homeobox NDUFA9: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 NDUFS4: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4 NES: Normalized enrichment score NGN2: Neurogenin-2 NIM: Neuronal induction medium non-oxPPP: Non-oxidative pentose phosphate pathway NRF-1: Nuclear respiratory factor 1 NT-3: Neurotrophin-3 Mal: Malate MAP2: Microtubule-associated protein 2 MELAS: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome mt-CO2: Cytochrome c oxidase subunit 2 OCT4: Octamer-binding transcription factor 4 OAA: Oxaloacetate OLIG: Oligomycin OXPHOS: Oxidative phosphorylation oxPPP: Oxidative pentose phosphate pathway PARK2: Parkinson protein 2 PGC-1 : Proliferating activating receptor coactivator-1 PGD: Phosphogluconate dehydrogenase PGLS: 6-Phosphogluconolactonase PPP: Pentose phosphate pathway RT-qPCR: Reverse transcription quantitative polymerase chain reaction RBFOX3: RNA binding fox-1 homolog 3 REX1: Reduced expression 1 (zinc finger protein 42) Rib5P: Ribose 5-phosphate ROS: Reactive oxygen species ROT: Rotenone ROX: Residual oxygen consumption RPE: Ribulose-phosphate 3-epimerase RPIA: Ribose 5-phosphate isomerase A SDHA: Succinate dehydrogenase [ubiquinone] flavoprotein subunit SOX2: SRY-box transcription factor 2 Suc: Succinate SURF1: Surfeit locus protein 1 SYP: Synaptophysin TALDO1: Transaldolase 1 TBP: TATA-box-binding protein TCA: Tricarboxylic acid TFAM: Mitochondrial transcription factor A TKT: Transketolase tRNA: Transfer ribonucleic acid TUBB3: Tubulin beta 3 class III UQCRC2: Cytochrome b-c1 complex subunit 2 VTN: Vitronectin References Schuchmann S, Buchheim K, Heinemann U, Hosten N, Buttgereit F (2005) Oxygen consumption and mitochondrial membrane potential indicate developmental adaptation in energy metabolism of rat cortical neurons
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It is well-known that with acute kidney injury, serum phosphate levels rise
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It suits studies exploring complex peptide interactions for systemic balance and neurological function
