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Reuter SE et al

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While some users described only mild side effects, such as constipation or nausea that became manageable after changing their diet, others talked about weeks or even months of severe diarrhea, bloating, chest pain, heartburn, and feeling full after only a few bites

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26 Experiments in pancreatic islets reveal that -arrestin limits the insulin response to GLP-1, but not GIP or tirzepatide, suggesting that the biased agonism and imbalance of tirzepatide toward the GIP receptor and its unique GLP-1 receptor signaling properties might be at the basis of its potent action

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M.WongB

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