Sublingual drops claim higher absorption than gastric tablets because the sublingual mucosa is thin, highly vascularized, and does not expose the peptide to stomach acid
A Mayo Clinic study in The Lancet [1] (2025) followed 400 postmenopausal women on tirzepatide for 12+ months: HRT + tirzepatide: 17% total body weight loss Tirzepatide alone: 14% or 35% less 45% of HRT users achieved 20% weight loss vs
The Body Adapts to Weigh Less The most fundamental reason for any weight-loss therapy plateau is that the body actively responds to weight loss by burning fewer calories
To begin with, GLP-1 is secreted by L cells in the lower intestine, and its secretory stimuli include nutrients, the gut microbiota itself, and metabolites of the gut microbiota, such as short-chain fatty acids 47,48
It is an older weight loss drug still considered to be effective
After 12 weeks, menopausal symptom scores decreased by 56% in the Pycnogenol group compared with 39% in the placebo group, and hot flashes and sleep difficulties were particularly improved