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1,5 PIONEER 4, PIONEER 2, and PIONEER 3 primary endpoint: Mean change in A1C from baseline at Week 26

[16] [17] For most people, particularly those without pre-existing retinopathy, these benefits far outweigh theoretical risks to vision

If period changes are bothering you, talk to your prescriber about adjusting the dose or trying another option

This mechanism makes it suitable for long-term use, though it requires commitment to behavioral change and continued treatment to sustain weight loss

R., Bryan, J., Hodgson, J

Clinical trial data from brand-name products should not be used to make decisions about compounded formulations