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The EMPA-REG OUTCOME trial detected slight elevations in nonfatal stroke events.11 In a subgroup analysis of the CANVAS trial, the results showed protective effects against haemorrhagic stroke, yet neutral effects on ischaemic stroke (HR 0.95

When taken by mouth, stomach acid breaks down most of the peptide before it can be absorbed into the bloodstream

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We then applied IC261 to test whether inhibition of VRK2 could make PDCs with high expression of VRK2 resensitization to GSH-targeting therapy

Reference: Gorouhi F & Maibach HI (2015)