We examine the role of receptor binding kinetics and -arrestin-biased signaling in the observed trafficking profiles, identifying a linked set of agonist characteristics optimally suited for insulin secretion, not shared by GLP-1R agonists in the current clinical use
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After 68 weeks, 16% reduction in body weight was noted in those who had received the drug, versus 5.7% in the placebo cohort
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doi:10.1056/NEJMoa2301972 7
