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Although our mouse studies suggest that tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the species difference in receptor pharmacology may limit extension of this interpretation to humans 25,26
10.1038/s41598-018-31749-z 59 KaufmannR
For those interested in a gentler approach, microdosing tirzepatide has gained attention as a way to start at even lower doses than the standard protocol suggests
Shingu M, and Nobunaga M (1984)
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